As federal agencies accelerate cloud adoption and modern application development, cyber risk is increasingly embedded inside the software supply chain itself. From open-source dependencies to container images and automated CI/CD pipelines, adversaries are exploiting the earliest stages of development to gain downstream access to federal environments. Securing software can no longer be an afterthought or a final gate. It must be continuous, automated, and integrated across the entire development lifecycle. This session will explore how federal leaders are operationalizing Software Bills of Materials (SBOMs), strengthening pipeline security, and protecting cloud and containerized workloads as part of a modern, end-to-end software security strategy. Panelists will discuss how agencies are embedding security into DevSecOps, gaining visibility into components and dependencies, and reducing supply chain risk without slowing mission delivery.